Table 3:
Summary of secondary outcomes and sensitivity analyses
| Cohort characteristics | Measures of Association | |||||||
|---|---|---|---|---|---|---|---|---|
| Cephalosporins | Penicillins | Carbapenems | ||||||
| Outcome | Exposure Window | T Cell Content | aOR/subHR (95% CI) |
p value | aOR/subHR (95% CI) |
p value | aOR/subHR (95% a) |
p value |
| Grade II-IV aGVHD | Conditioning to day +7 | Any | 1.05 (0.83-1.32) | 0.710 | 1.24 (0.93-1.66) | 0.140 | 1.24 (1.02-1.51) | 0.035 |
| Time to grade II-IV aGVHD | Conditioning to GHVD onset | Any | 1.09 (0.73-1.63) | 0.660 | 1.02 (0.67-1.54) | 0.940 | 1.31 (0.99-1.72) | 0.059 |
| Time to grade III-IV aGVHD | Conditioning to GHVD onset | Any | 0.90 (0.55-1.49) | 0.700 | 1.52 (0.87-2.66) | 0.140 | 1.77 (1.25-2.52) | 0.001 |
| Time to grade II-IV lower GI aGVHD | Conditionng to GHVD onset | Any | 0.82 (0.57-1.17) | 0.267 | 1.25 (0.81-1.95) | 0.316 | 1.27 (0.91-1.78) | 0.163 |
| Grade II-IV aGVHD | Conditioning to day +7 | T-replete | 1.20 (0.90-1.60) | 0.220 | 1.41 (0.99-2.01) | 0.054 | 1.33 (1.00-1.76) | 0.046 |
| Grade II-IV aGVHD | Conditioning to day 0 | Any | 1.01 (0.82-1.23) | 0.590 | 1.10 (0.76-1.58) | 0.620 | 1.45 (1.05-2.02) | 0.026 |
| Grade II-IV aGVHD | Day 0 to day +7 | Any | 1.07 (0.85-1.35) | 0.590 | 1.12 0.84-1.49 | 0.450 | 1.17 (0.96-1.42) | 0.120 |
aOR adjusted Odds Ratio; subHR sub Hazard Ratio; aGVHD acute Graft Versus Host Disease; GI Gastrointestinal