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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: Transplant Cell Ther. 2020 Dec 21;27(2):177.e1–177.e8. doi: 10.1016/j.jtct.2020.10.012

Table 3:

Summary of secondary outcomes and sensitivity analyses

Cohort characteristics Measures of Association
Cephalosporins Penicillins Carbapenems
Outcome Exposure Window T Cell Content aOR/subHR
(95% CI)
p value aOR/subHR
(95% CI)
p value aOR/subHR
(95% a)
p value
Grade II-IV aGVHD Conditioning to day +7 Any 1.05 (0.83-1.32) 0.710 1.24 (0.93-1.66) 0.140 1.24 (1.02-1.51) 0.035
Time to grade II-IV aGVHD Conditioning to GHVD onset Any 1.09 (0.73-1.63) 0.660 1.02 (0.67-1.54) 0.940 1.31 (0.99-1.72) 0.059
Time to grade III-IV aGVHD Conditioning to GHVD onset Any 0.90 (0.55-1.49) 0.700 1.52 (0.87-2.66) 0.140 1.77 (1.25-2.52) 0.001
Time to grade II-IV lower GI aGVHD Conditionng to GHVD onset Any 0.82 (0.57-1.17) 0.267 1.25 (0.81-1.95) 0.316 1.27 (0.91-1.78) 0.163
Grade II-IV aGVHD Conditioning to day +7 T-replete 1.20 (0.90-1.60) 0.220 1.41 (0.99-2.01) 0.054 1.33 (1.00-1.76) 0.046
Grade II-IV aGVHD Conditioning to day 0 Any 1.01 (0.82-1.23) 0.590 1.10 (0.76-1.58) 0.620 1.45 (1.05-2.02) 0.026
Grade II-IV aGVHD Day 0 to day +7 Any 1.07 (0.85-1.35) 0.590 1.12 0.84-1.49 0.450 1.17 (0.96-1.42) 0.120

aOR adjusted Odds Ratio; subHR sub Hazard Ratio; aGVHD acute Graft Versus Host Disease; GI Gastrointestinal