Table 6. Comparison of overall performance of the modified stNS1-ELISA, the modified stNS1-ELISA (plus) and NS1-RDT.

Assays	% overall sensitivity [95% CI]	% overall Specificity [95% CI]	% Diagnostic accuracy [95% CI]	% Sensitivity to serotype [95% CI]
				DENV1	DENV2	DENV3	DENV4
1. Modified stNS1-ELISA (4-pairs)	78.0 (156/200) [71.8–83.2]	100 (50/50) [92.9–100.0]	82.4 (206/250) [77.2–86.6]	62.0 (31/50) [48.2–74.1]	83.6 (46/55) [71.7–91.1]	84.4 (38/45) [71. 2–92.3]	82.0 (41/50) [69.2–90.2]
2. Modified stNS1-ELISA(plus) (5-pairs)	85.5 (171/200) [80.0–89.7]	100 (50/50) [92.9–100.0]	88.4 (221/250) [83.8–91.8]	90.0 (45/50) [78.6–95.7]	83.6(46/55) [71.7–91.1]	86.7 (39/45) [73.8–93.7]	82.0 (41/50) [69.2–90.2]
3. SD-NS1 RDT	73.5 (147/200) [70.0–79.1]	98.0 (49/50) [89.5–99.6]	78.4 (196/250) [73.0–83.1]	80.0 (40/50) [67.0–88.8]	69.1 (38/55) [56.0–79.7]	77.8 (35/45) [63.7–87.5]	68.0 (34/50) [54.2–79.2]
Exact McNemar test P-value (2 versus 3)	<0.001*	1.000	<0.001*	0.063	0.008*	0.125	0.016*

(*) indicated significantly difference between two assays (P < 0.05).