Table 1.
MR effect estimates of IVW, Weighted median and MR-Egger methods on the causal association of IPF with COVID-19 severity. Effect estimates are for all 15 IVs, 14 IVs without the rs35705950 at the MUC5B locus, and the 6 non-MUC5B IVs that do not associate with any other phenotype (Methods). IVs, genetic instrumental variables. OR, odds-ratio. CI Lower, lower confidence interval estimate. CI Upper, upper confidence interval estimate. P, p-value.
| Analysis | OR | 95% CI Lower | 95% CI Upper | P | Method |
|---|---|---|---|---|---|
| All 15 IVs | 1·054 | 0·924 | 1·203 | 4·31E-01 | IVW |
| 1·042 | 0·937 | 1·158 | 4·49E-01 | Weighted median | |
| 0.831 | 0.680 | 1·017 | 7·25E-02 | MR-Egger | |
| 14 IVs (no MUC5B) |
1·210 | 1·062 | 1·379 | 4·24E-03 | IVW |
| 1·188 | 1·074 | 1·315 | 8·62E-04 | Weighted median | |
| 1·296 | 0·669 | 2·510 | 4·43E-01 | MR-Egger | |
| 6 IVs (no other pheno) |
1·402 | 1·158 | 1·697 | 5·34E-04 | IVW |
| 1·349 | 1·164 | 1·565 | 7·30E-05 | Weighted median | |
| 1·233 | 0·442 | 3·439 | 6·89E-01 | MR-Egger | |
| 11 IVs (no MR-PRESSO outliers) |
1·194 | 1·106 | 1·290 | 5·48E-06 | IVW |
| 1·107 | 0·998 | 1·227 | 5·54E-02 | Weighted median | |
| 1·290 | 0·907 | 1·834 | 1·56E-01 | MR-Egger |