Table 2.
Effect estimates of rs35705950 at the MUC5B locus on COVID-19 severity (4336 cases & 623,902 controls; A2 analysis), hospitalization (6406 cases & 902,088 controls; B2 analysis) and susceptibility (14,134 cases & 1284,876 controls; C2 analysis). All, all the cohort. >60, sub-cohort of individuals older than 60 years. <60, sub-cohort of individuals younger than 60 years. The number of cases and controls for the age stratified analysis does not sum to the total number of cases and controls due to age missingnness in different cohorts. OR, odds-ratio of the IPF T risk allele. CI Lower, lower confidence interval estimate. CI Upper, upper confidence interval estimate. P, p-value. AF, allele frequency of rs35705950 T allele. N, sample size.
| Age | COVID-19 | OR | 95% CI Lower | 95% CI Upper | P | AF | N |
|---|---|---|---|---|---|---|---|
| All | Severity | 0·78 | 0·66 | 0·90 | 6·50E-05 | 0·108 | 628,238 |
| Hospitalization | 0·83 | 0·74 | 0·92 | 3·77E-05 | 0·112 | 908,494 | |
| Susceptibility | 0·93 | 0·88 | 0·99 | 9·18E-03 | 0·116 | 1299,010 | |
| >60 | Hospitalization | 0·86 | 0·73 | 1·00 | 2·99E-02 | 0·109 | 417,774 |
| Susceptibility | 0·87 | 0·77 | 0·98 | 9·48E-03 | 0·110 | 470,162 | |
| <60 | Hospitalization | 0·85 | 0·64 | 1·06 | 1·42E-01 | 0·112 | 83,265 |
| Susceptibility | 0·99 | 0·90 | 1·09 | 9·07E-01 | 0·107 | 314,152 |