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. 2021 Mar 10;7(11):eabe2888. doi: 10.1126/sciadv.abe2888

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Fig. 3 — (A) Fluorescence images of the mouse skin recorded at different time points after insertion of the MN patch into the skin. Scale bar, 500 μm. (B to E) Screening targeting sequence of sgNLRP3 to optimize the genome-editing efficiency in DC2.4 cells (B) and 3T3 cells (D) and Sanger sequencing results of T-A cloning from DC2.4 cells (C) and 3T3 cells (E) after CMAX-mediated transfection. WT, wild type; N.D., not detectable. (F and G) T7E1 assay of indels introduced into the NLRP3 locus in DC2.4 cells (F) and 3T3 cells (G) transfected with dual CP/Ad-SS-GD/RNP and PLGA/Dex nanoparticles. Means ± SD, n = 3, Student’s t test, **P < 0.01.