Figure 3. IL4i1 products induce specific stress and redox-protective gene expression programs.

(A–C) THP-1 human monocytic cells were trated for 24 hr with PP, 4HPP, or I3P (200 µM) and RNAseq analysis was used to quantify gene expression changes compared to untreated controls. (D) Top hits of GO term overrepresentation analysis of the most significantly (p-value cutoff p<10⁻⁹) upregulated genes by I3P treatment (left). The full table of significant GO terms is provided (Supplementary file 1). Heat map of genes detected in the analysis under the term GO:0006979 (right).