Table 1. Cases of sarcoidosis-lymphoma syndrome with skeletal involvement.
TBD = time-before-diagnosis of concurrent sarcoidosis-lymphoma; M = male; F = female; mo = month; DLBCL = diffuse large B-cell lymphoma; R-CHOP = rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, and prednisone; MTX = methotrexate; Gy = gray
| Study | Year | Age | Initial Dx | TBD | Sex | Lymphoma Type | Clinical presentation | Treatment | Tumor Location | Histopathology | Outcome | Reccurence? | Last follow up (mo) |
| Mori et al. [11] | 2009 | 63 | Sarcoidosis | 1 mo | F | B-cell Lymphoma | Back pain | R-CHOP | Lumbar vertebra | Noncaseating granulomas with CD5+, CD20+ tumor cells showing K-chain monoclonality | Complete response | No | N/A |
| Kobayashi et al. [12] | 2001 | 57 | Lymphoma | 1.5 mo | F | DLBCL | Right foot pain and swelling | CHOP | Right talus | Epithelioid granuloma with | Some response | No | 12 |
| Marks et al. [13] | 2018 | 54 | Sarcoidosis | 7 yr | M | DLBCL | Pain and swelling in both ankles | R-CHOP + MTX + local 36 Gy Radiotherapy | Bilateral distal tibiae | Diffuse infiltrates of CD20+ lymhoid cells | Complete response | No | 56 |
| Di et al. (current study) | 2019 | 72 | Lymphoma | 1 mo | M | DLBCL | Diplopia, headache, dysarthria | R-CHOP + Dexamethasone + MTX | C1, L1, L5 vertebrae; right iliac, left inferior sacrum | CD10+, CD20+, Bcl2+, FISH+ for t(14;18) | Complete response | No | 2.3 |