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. 2020 Sep 23;14(2):431–442. doi: 10.1038/s41385-020-00344-9

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© the Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Representative flow cytometry plot showing the distribution of cDC1, cDC2, and moDCs in the lungs of an 18-month-old WT and pIgR^−/− mouse (from CD11c⁺MHC II^hi cells). b Percentage of cDC1, cDC2, and moDCs among CD11c⁺MHCII^hi cells in 18-month-old WT and pIgR^−/− mice shown in (a). c Percentage of moDCs expressing the activation markers pRelA, TNFR1, and CD86 in 18-month-old WT and pIgR^−/− mice. d, e Percentage proliferating OT-I (d) or OT-II (e) splenic T lymphocytes co-cultured with lung CD11b⁺ cells from 18-month-old WT or pIgR^−/− mice at the ratios indicted (CD11b⁺ cells to T cells) in the presence of OVA peptide. b, c *p < 0.01 compared to 18-month-old WT mice (t-test); n = 4 mice/group. d *p < 0.05 for trend (1-way ANOVA); n = 3 biological replicates (CD11b⁺ cell donors)/group and 3 technical replicates per biological replicate. OT-I or OT-II cells came from spleens of a single donor for each experiment. Box-and-whisker plots represent median, interquartile range, and range.