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. 2020 Nov 2;14(2):443–454. doi: 10.1038/s41385-020-00349-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Survival of indicated host TCR^mini, EpTCR^mini or 63KTCR^mini mice receiving adoptive transfer of naïve or anergic CD4⁺ cells from indicated donors (n = 6 EpTCR^mini Tn->EpTCRα^k/o, n = 7 EpTCR^mini Tn->63KTCRα^k/o, n = 10 EpTCR^mini Tn->TCRα^k/o, n = 9 EpTCR^mini Tan->EpTCRα^k/o, n = 6 EpTCR^mini Tan->63KTCRα^k/o, n = 6 EpTCR^mini Tan->TCRα^k/o). Representative FACS analysis of mice from a. A typical expression of Foxp3, FR4/CD73, and PD-1 is shown for each host mouse type. b represents naïve and c Tan cell transfer. Data are summarized in d for Tn and e for Tan transfers, with each symbol indicating individual animal. Mice expressing symptoms of wasting disease were analyzed when they lost <15% of original starting weight. Statistical significance was calculated by ANOVA with Bonferroni correction. For survival (a), the log-rank test was applied. *p < 0.05, **p < 0.01, ***p < 0.001.