Fig. 4.

Cocaine-specific effects on Rab GTPases. To examine the expression of Rab GTPases in microglial cells, cells were incubated with 10 nM, 100 nM, 1 µM, 10 µM, and 100 µM cocaine for 24 h, and Rab protein expression levels were evaluated in BV2 cells and exosomes using dot blot analysis. a Rab7, b Rab11, c Rab27A and d Rab35 expression in BV2 cell-derived exosomes. Statistical significance derived from 5 independent experiment in triplicates is indicated the mean of SD as follows: *p < 0.05; **p < 0.001; and ***p < 0.0001