Table 2.
Comparative susceptibility data with MIC ranges and GM (μg/mL) of T. rubrum from studies in China and other countries with CLSI M38-A2
| Number† | Location (no. of isolated) | Year | Incubationtime (day) | Inoculum size (CFU/ml) | Temp. (ºC) | MIC†† (μg/ml) | Azoles | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Topical | Systemic | |||||||||||
| LLCZ | BFZ | MCZ | KTZ | FCZ | ITZ | |||||||
| 1 | Germany(7) | 2009 | 4–5 days | 6.25 × 103 | 35 | Range | – | < 0.0005 | – | – | – | – |
| GM | – | < 0.0005 | – | – | – | – | ||||||
| 2 | Tianjing (50) | 2013 | 4–7 days | 2–3 × 103 | 35 | Range | – | – | – | – | 1–4 | 0.03–0.12 |
| GM | – | – | – | – | 1.117 | 0.055 | ||||||
| 3 | Brazil (37) | 2013 | 7 days | 2–4 × 104 | 28 | Range | – | – | – | ≤ 0.031–4 | 2- ≥ 64 | ≤ 0.031–1 |
| GM | – | – | – | 0.46 | 11.2 | 0.22 | ||||||
| 4 | USA (308) | 2013 | 4 days | 1–3 × 103 | 30 | Range | 0.00012–0.0025 | – | – | 0.062–8 | 0.015–16 | |
| GM | 0.00022 | – | – | 1.34 | 0.037–0.247 | |||||||
| 5 | India (40) | 2014 | 7 days | 0.5–5 × 104 | 28 | Range | – | – | – | 0.01–3.84 | 0.16–20.48 | 0.03–3.84 |
| MIC50 | – | – | – | 0.24 | 1.28 | 0.24 | ||||||
| 6 | Japan (62) | 2015 | 4 days | 0.5 × 103 | 35 | Range | – | – | – | – | – | 0.015–0.25 |
| MIC50 | – | – | – | – | – | 0.12 | ||||||
| 7 | India (35) | 2015 | 4 days | 1–3 × 103 | 37 | Range | – | – | – | 0.25 -1 | 0.125—2 | – |
| GM | – | – | – | 0.5 | 2 | – | ||||||
| 8 | India (18) | 2015 | 4–5 days | 2–6 × 103 | 35 | Range | – | – | – | 0.0156–0.5 | 0.0156–1 | |
| GM | – | – | – | 0.1954 | 0.1918 | |||||||
| 9 | Iran (60) | 2015 | 3–5 days | 1–3 × 103 | – | Range | – | – | – | – | 8–64 | 0.16–0.5 |
| GM | – | – | – | – | 22.49 | 0.088 | ||||||
| 10 | Shanghai (55) | 2016 | 96 h | 1–5 × 104 | 28 | Range | – | 0.03– > 16 | 0.03–16 | 0.03- > 16 | 0.125- > 64 | 0.03- > 16 |
| GM | – | 0.11 | 0.05 | 0.03 | 0.96 | 0.13 | ||||||
| 11 | Iran (13) | 2016 | 4 days | 0.4–5 × 104 | 30 | Range | – | – | – | 0.06–2 | 0.5–32 | 0.03–0.5 |
| GM | – | – | – | 0.26 | 2.75 | 0.13 | ||||||
| 12 | Iran (29) | 2016 | 4 days | 0.5–3 × 103 | 35 | Range | 0.016– 16 | – | 0.25–8 | – | 4–64 | 0.063–0.5 |
| GM | 0.02 | – | 3.31 | – | 9.9 | 0.18 | ||||||
| 13 | Beijing (20) | 2017 | 5–7 days | 1–3 × 103 | 35 | Range | 0.015–0.25 | 0.015–1 | 0.015–0.5 | 0.03–1 | – | – |
| GM | 0.036 | 0.035 | 0.048 | 0.109 | – | – | ||||||
| 14 | India (5) | 2017 | – | 1–3 × 103 | 28–30 | Range | – | – | – | – | – | 0.03–0.06 |
| GM | – | – | – | – | – | 0.039 | ||||||
| 15 | India (29) | 2017 | – | – | – | Range | – | – | – | – | 0.03–16 | 0.03–0.5 |
| MIC50 | – | – | – | – | 4 | 0.03 | ||||||
| 16 | Wuhan (17) | 2018 | 5–7 days | 1–5 × 104 | 28 | Range | < 0.031 | – | 1–16 | 0.18–1 | 4–64 | 0.5–8 |
| GM | < 0.031 | – | 2.26 | 0.28 | 7.67 | 3.01 | ||||||
| 17 | Iran (54) | 2018 | 4 days | 1–3 × 103 | 35 | Range | 0.0005 -0.002 | – | – | – | 8–64 | 0.03–0.25 |
| GM | 0.0004 | – | – | – | 15.19 | 0.077 | ||||||
| 18 | Iran (20) | 2018 | 4 days | – | 35 | Range | – | – | – | 0.06–8 | – | 0.01–8 |
| GM | – | – | – | 0.28 | – | 0.05 | ||||||
| 19 | India | 2018 | 5 days | 0.5–5 × 104 | 28 | Range | 0.0312–0.25 | – | – | 0.0625–1 | 2–32 | 0.015–1 |
| (35) | GM | 0.0509 | – | – | 0.13 | 4.08 | 0.09 | |||||
| 20 | Henan (50) | 2019 | 7 days | 1–3 × 103 | 28 | Range | – | – | – | 0.5–2 | 16–32 | 0.063–0.125 |
| GM | – | – | – | 1.3013 | 25.992 | 0.0848 | ||||||
| 21 | Shengzhen (68) | 2019 | 4–5 days | 0.5–2.5 × 103 | 35 | Range | – | – | – | 0.25–2 | 1- > 64 | 0.06–2 |
| GM | – | – | – | 0.744 | 15.518 | 0.535 | ||||||
| 22 | India (36) | 2019 | 4 days | 1–3 × 104 | 35 | Range | – | – | – | 0.06–1 | 0.125–1 | 0.125–2 |
| MIC90 | – | – | – | 0.25 | 1 | 0.5 | ||||||
| 23 | India (13) | 2019 | 5–7 days | 1–3 × 103 | 35 | Range | – | – | – | 0.125–0.5 | 2–64 | 0.125–2 |
| MIC50 | – | – | – | 0.06 | 4 | 0.125 | ||||||
| 24 | India (18) | 2019 | – | – | – | Range | – | – | – | – | – | 0.0625–1 |
| GM | – | – | – | – | – | 0.18 | ||||||
| 25 | Iran (10) | 2020 | 4 days | 1–3 × 103 | 35 | Range | 0.0005–0.004 | – | – | 0.03–0.5 | 4- 64 | 0.03- 16 |
| GM | 0.0005 | – | – | 0.0604 | 8 | 0.1871 | ||||||
| 26 | Beijing (62) | 2020 | 5–7 days | 1–3 × 103 | 35 | Range | 0.002–0.06 | 0.004–0.25 | 0.004–0.25 | 0.015–0.25 | 1.00–4 | 0.015–0.5 |
| GM | 0.016919 | 0.033345 | 0.060586 | 0.057188 | 1.617256 | 0.120875 | ||||||
| Number† | Allylamines | Morpholines | References | |
|---|---|---|---|---|
| Systemic or topical | Topical | |||
| TBF | NAF | AMF | ||
| 1 | – | – | 0.125–0.5 | [36] |
| – | – | 0.375 | ||
| 2 | 0.04–0.32 | – | – | [30] |
| 0.135 | – | – | ||
| 3 | ≤ 0.031–0.062 | – | – | [37] |
| 0.06 | – | – | ||
| 4 | 0.004–0.25 | – | 0.008–0.5 | [38] |
| 0.0194 | – | 0.0883 | ||
| 5 | 0.001–0.08 | – | – | [39] |
| 0.005 | – | – | ||
| 6 | 0.004–0.03 | – | 0.015–0.25 | [40] |
| 0.015 | – | 0.06 | ||
| 7 | 0.001–0.008 | – | – | [41] |
| 0.004 | – | – | ||
| 8 | 0.0313–4 | – | – | [42] |
| 0.7378 | – | – | ||
| 9 | 0.004–0.125 | – | – | [43] |
| 0.017 | – | – | ||
| 10 | 0.0075- > 4 | – | – | [31] |
| 0.04 | – | – | ||
| 11 | – | – | – | [44] |
| – | – | – | ||
| 12 | 0.008–0.25 | – | – | [45] |
| 0.06 | – | – | ||
| 13 | 0.004–0.03 | 0.004–0.03 | 0.015–0.06 | [32] |
| 0.012 | 0.013 | 0.023 | ||
| 14 | 0.03–8.0 | – | – | [46] |
| 0.0863 | – | – | ||
| 15 | 0.015–16 | – | – | [6] |
| 0.063 | – | – | ||
| 16 | 0.031–1 | – | – | [33] |
| 0.33 | – | – | ||
| 17 | 0.004–0.06 | – | – | [47] |
| 0.009 | – | – | ||
| 18 | 0.003- > 32 | – | – | [18] |
| 0.04 | – | – | ||
| 19 | 0.015–16 | 0.0312–16 | 0.007–0.625 | [5] |
| 0.05 | 0.007 | 0.02 | ||
| 20 | 0.002–0.008 | – | – | [34] |
| 0.0045 | – | – | ||
| 21 | 0.016–0.064 | – | – | [35] |
| 0.032 | – | – | ||
| 22 | 0.008–0.256 | – | – | [48] |
| 0.064 | – | – | ||
| 23 | 0.5–32 | – | – | [49] |
| 2 | – | – | ||
| 24 | 0.0312–8 | – | – | [19] |
| 1.1866 | – | – | ||
| 25 | 0.003–0.25 | – | – | [50] |
| 0.0678 | – | – | ||
| 26 | 0.001–0.015 | 0.008–0.06 | 0.015–0.125 | Our study |
| 0.00688 | 0.02037 | 0.05271 | ||
†UL-WT was determined for seven studies (13, 14, 20, 23, 24, 25, 26)
††Several studies (5, 6, 15, 23) indicated MIC50 values rather than GM MIC values; one study (22) indicated MIC90 values
“–”: Data was not available