Table 2.
Cancer-specific survival adjusted hazard ratios characterizing the association of patient, tumor, and treatment characteristics between GI melanoma and cutaneous melanoma 1988-2016 (n=243,627)
| Model 1: All Patients (GI + Cutaneous Melanoma) (N=243,627) |
Model 2: Cutaneous Melanoma Only (N=243,186) |
Model 3: Anorectal Melanoma Only (N=369) |
|||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | HR | 95% CI | ||
| Cancer Type | Cutaneous Melanoma | 1.00 | REF | - | - | - | - |
| Anorectal Melanoma | 3.38 | (2.96, 3.85) | - | - | - | - | |
| Other GI site Melanoma | 2.36 | (1.75, 3.18) | - | - | - | - | |
| Age at diagnosis | 18-49 | 0.36 | (0.35, 0.37) | 0.41 | (0.40, 0.43) | 0.62 | (0.40, 0.95) |
| 50-69 | 0.54 | (0.53, 0.56) | 0.58 | (0.57, 0.60) | 1.04 | (0.78, 1.38) | |
| 70-100 | 1.00 | REF | 1.00 | REF | 1.00 | REF | |
| Sex | Female | 0.66 | (0.65, 0.68) | 0.68 | (0.66, 0.70) | 0.94 | (0.72, 1.23) |
| Male | 1.00 | REF | 1.00 | REF | 1.00 | REF | |
| Race | White | 1.00 | REF | 1.00 | REF | 1.00 | REF |
| Non-White | 0.75 | (0.69, 0.81) | 0.73 | (0.67, 0.79) | 1.13 | (0.82, 1.57) | |
| Married | Yes | 1.00 | REF | 1.00 | REF | 1.00 | REF |
| No | 1.09 | (1.06, 1.12) | 1.08 | (1.05, 1.11) | 0.92 | (0.70, 1.21) | |
| Year of diagnosis | 1988-1994 | 1.00 | REF | 1.00 | REF | 1.00 | REF |
| 1995-2001 | 0.85 | (0.80, 0.90) | 0.85 | (0.81, 0.90) | 1.17 | (0.66, 2.05) | |
| 2002-2008 | 0.82 | (0.77, 0.87) | 0.79 | (0.74, 0.83) | 1.04 | (0.62, 1.77) | |
| 2009-2016 | 0.72 | (0.68, 0.77) | 0.67 | (0.63, 0.71) | 0.73 | (0.43, 1.25) | |
| SEER Summary Stage | Localized | 1.00 | REF | 1.00 | REF | 1.00 | REF |
| Regional | 6.96 | (6.75, 7.17) | 3.61 | (3.48, 3.74) | 1.53 | (1.08, 2.17) | |
| Distant | 19.30 | (18.27, 20.40) | 10.36 | (9.77, 10.99) | 3.02 | (2.04, 4.48) | |
| Tumor Sizea | <2 mm/cm | - | - | 1.00 | REF | 1.00 | REF |
| 2-<5 mm/cm | - | - | 3.14 | (3.03, 3.26) | 1.21 | (0.85, 1.72) | |
| >=5 mm/cm | - | - | 4.02 | (3.85, 4.20) | 1.23 | (0.82, 1.83) | |
| Treatment | No Treatment | 1.00 | REF | 1.00 | REF | 1.00 | REF |
| Major surgery only | 0.94 | (0.84, 1.04) | 0.81 | (0.73, 0.91) | 0.27 | (0.14, 0.53) | |
| Major surgery & radiation | 1.95 | (1.57, 2.43) | 1.58 | (1.26, 1.99) | 0.30 | (0.13, 0.72) | |
| Local excision & chemotherapy | 1.73 | (1.54, 1.95) | 1.46 | (1.30, 1.65) | 0.33 | (0.15, 0.74) | |
| Local excision & radiation | 1.67 | (1.48, 1.87) | 1.27 | (1.13, 1.44) | 0.34 | (0.15, 0.73) | |
| Local excision & radiation & chemotherapy | 3.16 | (2.72, 3.67) | 2.70 | (2.32, 3.16) | 0.35 | (0.15, 0.83) | |
| Chemotherapy only | 2.28 | (1.70, 3.05) | 3.20 | (2.34, 4.39) | 0.36 | (0.15, 0.88) | |
| Local tumor excision only | 0.68 | (0.62, 0.75) | 0.64 | (0.58, 0.71) | 0.40 | (0.21, 0.75) | |
| Major surgery & chemotherapy | 2.34 | (1.95, 2.81) | 1.87 | (1.54, 2.27) | 0.52 | (0.26, 1.05) | |
| Radiation only | 4.07 | (3.21, 5.15) | 5.74 | (4.44, 7.41) | 0.53 | (0.24, 1.14) | |
| Radiation & chemotherapy | 3.45 | (2.49, 4.79) | 4.27 | (2.94, 6.21) | 0.53 | (0.23, 1.23) | |
| Major surgery & radiation & chemotherapy | 2.32 | (1.62, 3.33) | 2.68 | (1.85, 3.89) | b | b | |
a
Tumor size is thickness in mm for cutaneous melanoma and size in cm for GI melanoma
b
Treatment category “Major surgery and radiation and chemotherapy” was excluded from Model 3 due to small numbers