Table 3a.
Multivariable logistic regression model assessing the association between risk factors, including early (2-week) PTSD symptom severity as assessed by the PCL-5, and PTSD at 3-months post- injury (n=405).
| OR | 95% CI | Chi-sq | p-value | |
|---|---|---|---|---|
| PC1 | .65 | 0.49–0.87 | 8.75 | .003 |
| ICV (standardized) | 2.03 | 1.19–3.48 | 6.67 | .01 |
| Male (ref: Female) | .72 | 0.31–1.68 | .58 | .45 |
| Black (ref: White/Other) | 1.05 | 0.42–2.63 | .01 | .92 |
| Hispanic (ref: White/Other) | 1.31 | 0.50–3.38 | .30 | .58 |
| Years of Education | .96 | 0.84–1.10 | .31 | .58 |
| Any psychiatric history (ref: None) | 1.89 | 0.84–4.28 | 2.35 | .13 |
| Any prior TBI (ref: None) | 1.63 | 0.81–3.28 | 1.90 | .17 |
| Violent injury cause (ref: Accidental) | 1.40 | 0.39–5.10 | .26 | .61 |
| PCL-5 Total Score at week 2 | 1.09 | 1.07–1.12 | 65.54 | < .001 |
PC1: first principal component that explained 73.8% of the variance in the regional volumes of the insula, superior frontal cortex, and rostral and caudal anterior cingulate.