Table 3b.
Multivariable zero-inflated negative binomial regression model assessing the association between risk factors and PCL-5 Hyperarousal subscale at 3-months post-injury (n=405)
FC | 95% CI | p-value | OR | 95% CI | p-value | |
---|---|---|---|---|---|---|
PC1 | .94 | 0.88–0.99 | .031 | 1.27 | 0.99–1.64 | .06 |
ICV (standardized) | 1.13 | 1.00–1.27 | .049 | .79 | 0.49–1.26 | .31 |
Male (ref: Female) | .99 | 0.82–1.19 | .89 | .96 | 0.44–2.11 | .92 |
Black (ref:White/Other) | 1.21 | 0.99–1.48 | .063 | 1.48 | 0.63–3.44 | .37 |
Hispanic (ref: non-Hispanic) | 1.09 | 0.89–1.33 | 0.43 | 1.66 | 0.66–4.18 | .28 |
Education (y) | .96 | 0.93–0.99 | 0.013 | 1.11 | 0.98–1.25 | .09 |
Any psychiatric history (ref: None) | 1.16 | 0.96–1.40 | 0.128 | 2.06 | 0.77–5.52 | .15 |
Any prior TBI (ref: None) | 1.17 | 0.997–1.37 | 0.055 | 1.35 | 0.68–2.67 | .39 |
Violent injury cause* (ref: Accidental) | 1.05 | 0.79–1.39 | 0.76 | -- | -- | -- |
PCL-5 Hyperarousal at week 2 | 1.07 | 1.05–1.08 | <0.001 | 1.35 | 1.20–1.50 | <0.001 |
PC1: first principal component that explained 73.8% of the variance in the regional volumes of the insula, superior frontal cortex, and rostral and caudal anterior cingulate
FC: Estimated fold change with 95% confidence interval of the predictor variable associated with severity of hyperarousal symptoms when the symptoms are present.
OR: Estimated odds ratio with 95% confidence interval of the predictor variable associated with presence (non-zero scores) vs. absence (zero scores) of hyperarousal symptoms.
Injury cause was not modeled in the zero-inflation part due to zero-count in one of the cells which would lead to an infinite confidence interval.