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. Author manuscript; available in PMC: 2022 Mar 15.
Published in final edited form as: J Immunol. 2021 Feb 10;206(6):1329–1336. doi: 10.4049/jimmunol.2000969

Figure 1. Heatmap of selected PTK inhibitors identified in high throughput screening.

Figure 1.

Effect of inhibitors was measured by LDH (pyroptosis) and IL-18 release (inflammasome activation) following LPS/ATP or bacterial stimulation of THP-1 cells and expressed as fold differences relative to the LPS/ATP DMSO inhibitor control (defined as 1.0). Cells were pretreated with three different concentrations of PTK inhibitors 30 min prior to LPS stimulation for 30 min followed by ATP treatment for another 30 min (A), or infected with 100 MOI of F. novicida and 10 MOI of B. cenocepacia for 6 h (B). AG126 was used as a positive control reference inhibitor for LDH and IL-18 inhibition. Detailed readouts for all inhibitors from the library are shown in Supplementary Figure 1.