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. 2021 Jan 11;77(4):1234–1244. doi: 10.1161/HYPERTENSIONAHA.120.16113

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© 2021 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 4. — It compares patients with postural tachycardia syndrome (POTS) treated with pyridostigmine (blue lines) with control (black lines) supine and during head-up tilt (HUT). Operating points are shown by blue and black circles. G_max is restored to near control values supine and upright. Supine systolic arterial pressure (SAP) at centering and operating points are similar to control, but threshold is displaced downwards and response range is curtailed. During tilt centering point, SAP and G_max were sustained but response range was greatly reduced during tilt contributing to the left shift of the operating point.