Table 3-.

Measured parameters by fluid status: resuscitation and overload phase

Fluid Status:	0 mL	500 mL	1,000 mL	1,500 mL	2,000 mL	2,500 mL	P
Vital Sign Parameters
Heart Rate (beats per minute)	99±16	96±14	95±13	95±13	99±9	101±9	0.183
SBP (mmHg)	89±9	89±13	89±15	89±15	91±13	91±12	0.750
DBP (mmHg)	58±11	57±14	57±15	57±14	59±12	59±12	0.700
MAP (mmHg)	72±10	71±14	72±16	72±15	73±13	74±12	0.669
Pulse Pressure (mmHg)	33±6	32±7	32±7	32±7	32±7	32±7	0.421
Pulse Pressure Variation	20±12	16±11	11±3	10±4	8±2	11±7*	0.055
Central Hemodynamic Parameters
MPAP (mmHg)	17±4	20±5*	22±5***	23±5****	23±4****	24±4***	<0.0001
PCWP (mmHg)	8±3	10±3	12±4*	15±3****	16±3***	17±3****	<0.0001
CVP (mmHg)	6±4	9±4*	11±4***	13±4****	13±4****	14±4****	<0.0001
CO (L/min)	4.3±1.3	4.4±1.1	4.6±0.88	5.1±1.3	5.1±1.5	5.7±1.0**	<0.0001

Values are reported with their standard deviations

P values reflect one-way ANOVA analysis

Relative to 0 milliliters (mL):

^*P<0.05

^**P≤0.01

^***P≤0.001

^****P≤0.0001