Liver toxicity after micelle injection was evaluated by H&E and ALT/AST activity. Mice were injected i.v. with PBS, LMM, or DMM (5 mg/kg) on days 0 and 4. Six hours after the 2nd injection, mice were sacrificed and livers and serum were collected for H&E staining (A-C) or liver enzyme (ALT, AST) analysis (D, E). H&E images are at 10X magnification (n = 3 mice/group). (For ALT/AST analysis, n = 4–5 mice/group)