Table 2.

Summary of the natural compounds with brain boosting activity.

S. no	Brain boosting compounds	Category	Reported mechanism of action
1	Epigallocatechin gallate (EGCG)	Polyphenol	Cross (BBB) model and protect neurons from oxidative-stress-induced cell death [28]8
2	Resveratrol	Polyphenol	-Modulate growth of dendrites and axons [29] -Decrease neuroinflammation [30] -Activates protein kinase C gamma that help in neuroprotection [31]
3	Lectins •Con A •Dvl	Protein	-Release of proinflammatory cytokines like IL-1β and IL-18 -Induce intracellular Ca2+ mobilization -Reduce apoptosis and ROS generation [32]
4	Chlorogenic acid (CGA)	Polyphenols	Reduce proinflammatory Mediators [33]
5	Caffeine	Polyphenols	Bring down oxidative Stress which plays role in depression & pathophysiology of anxiety [33]
6	Ferulic acid	Polyphenols	-Decrease depressive behavior and pain decreased -Reduce neuroinflammation -Regulate oxidative/antioxidant defense [33]

BBB-human blood–brain barrier, Con A-concanavalin A, Dvl-Dioclea violacea.