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. 2021 Feb 25;12:629986. doi: 10.3389/fimmu.2021.629986

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Copyright © 2021 Kunz and Kemper

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Proposed involvement of the complosome in behavioral control. The direct effect on brain development by classical complement system is well established: C1q and C3 mediate synaptic pruning, neurogenesis, cognitive functions and are important for mental health (green text). Likewise, the role of complement and the complosome in particular in the control of local T cell responses via metabolic reprogramming has been well described (gray triangle, see text for details). We propose that the complosome is heavily involved in most of the known effects of T cells, metabolism and cytokines (IFN-γ and IL-10) on neural functions underlying cognition and behavior.