Table 1.

Univariate and multivariate analysis.

	Univariate			Multivariate
	HR	CI	P values	HR	CI	P values
Response	2.77	1.64–10.07	0.003	1.23	0.88–1.73	0.232
ISS stage	3.67	1.29–8.22	0.013	0.24	0.077-0.75	0.014
Tregs LAG-3+	2.01	1.04–4.44	0.046	1.35	0.55–3.29	0.508
CD4eff PD-1+	1.99	1.07–4.75	0.042	3.55	1.39–9.07	0.008
CD8 Ki-67+	2.36	1.17–4.93	0.047	1.35	0.55–3.29	0.007