Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 25;12:636061. doi: 10.3389/fimmu.2021.636061

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Borchers, Santos-Valente, Toncheva, Wehkamp, Franke, Gaertner, Nordkild, Genuneit, Jensen and Kabesch

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

DEFB4 locus on chromosome 8p23.1 with surrounding genes and pseudogenes (A) and location of the 40 selected SNPs for genotyping in GABRIELA Ulm (B). (A) Red dots: A-copies of the β-defensin genes; orange dots: B-copies of the β-defensin genes; red and orange dots with black circle: DEFB4 genes. Blue dots: unknown genes; yellow dots: FAM90A-pseudogenes; purple dots: PRR23-genes and OR7E-pseudogenes; brown dots: SPAG11-genes; green dots: HSPD1-pseudogenes; grey dots: ZNF705-genes. The hatched rectangle in the middle represents a not yet sequenced 50 Kb area, which presents like a mirror in this cluster. (B) positions of the selected SNPs for genotyping are shown as black vertical lines with numbers in relation to the position of DEFB4A and DEFB4B. Circled numbers represent SNPs that were successfully genotyped. Black boxes refer to exonic regions, white boxes to UTRs, hatched boxes to putative promoter regions.