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. 2021 Feb 25;12:636061. doi: 10.3389/fimmu.2021.636061

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Copyright © 2021 Borchers, Santos-Valente, Toncheva, Wehkamp, Franke, Gaertner, Nordkild, Genuneit, Jensen and Kabesch

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lung resistance (A) and compliance (B) in 6 mice per group 48 h after saline or HDM challenge. Saline: Mice without treatment and challenged with saline only. Vehicle/HDM: Mice prophylactically treated with vehicle and challenged with HDM. hBD-2/HDM: Mice prophylactically treated with hBD-2 and challenged with HDM. *significant difference (ANOVA with post-hoc t-test; p<0.05) between vehicle treated and hBD-2–treated mice; ^#significant difference (ANOVA with post-hoc t-test; p<0.05) between saline-challenged and HDM-challenged mice. hBD-2, human beta-defensin 2; HDM, house dust mite.