Table 1.
Genetic associations of SNPs in or nearby DEFB4A/B with asthma and atopy in the GABRIELA Ulm cohort (n=1,238).
| MAF | Asthma | Atopy | Atopic asthma | Non-atopic asthma | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | SNP | Minor allele | CEU | GABRIELA Ulm | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) |
| 17 | rs533344477 | C | 0.005 | 0 | – | – | – | – | – | – | – | – |
| 12 | rs538653319 | C | 0.01 | 0 | – | – | – | – | – | – | – | – |
| 3 | rs538901702 | T | 0.005 | 0.0004 | 1.44-26 | NA | 5.67-33 | NA | 8.68-30 | NA | 4.59-23 | NA |
| 11 | rs543538872 | T | 0.015 | 0.002 | 2.42-90 | NA | 0.169 | 4.03 (0.55–29.28) |
9.14-82 | NA | 6.47-91 | NA |
| 2 | rs546946128 | A | 0.005 | 0 | – | – | – | – | – | – | – | – |
| 26 | rs558364144 | T | 0.005 | 0 | – | – | – | – | – | – | – | – |
| 35 | rs558912368 | A | 0.005 | 0 | – | – | – | – | – | – | – | – |
| 4 | rs562192342 | A | 0.005 | 0 | – | – | – | – | – | – | – | – |
| 1 | rs562864847 | G | 0.01 | 0.008 | 0.067 | 3.5 (0.91–13.41) |
0.732 | 1.27 (0.33–4.87) |
0.0273 | 4.79 (1.19–19.20) |
3.92-181 | NA |
| 7 | rs567390989 | T | 0.015 | 0.0008 | 0.077 | 12.19 (0.77–194.01) |
0.344 | 4.2487 (0.21–84.70) |
0.050 | 17.37 (0.99–304.04) |
4.38-23 | NA |
| 22 | rs62640720 | G | 0.328 | 0.0004 | 1.3-21 | NA | 5.22-28 | NA | 1.57-24 | NA | 1.15-18 | NA |
| 15 | rs6651513 | A | 0.116 | 0.046 | 0.155 | 0.56 (0.25–1.24) |
0.229 | 1.3935 (0.81–2.39) |
0.4755 | 0.74 (0.32–1.69) |
0.001 |
0.08
(0.02–0.35) |
| 14 | rs73199779 | C | 0.056 | 0.028 | 0.839 | 0.92 (0.39–2.14) |
0.281 | 0.6916 (0.35–1.35) |
0.446 | 0.66 (0.23–1.92) |
0.940 | 1.71 (0.50–5.92) |
SNP, single nucleotide polymorphism; CI, confidence interval; MAF, minor allele frequency; NA, not applicable; OR, odds ratio.
Bold values represent significant association of the SNP with the respective disease.