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. 2021 Feb 23;11:624395. doi: 10.3389/fonc.2021.624395

Figure 1.

Figure 1

Pan-cancer expression alterations and prognostic values of m6A regulators. (A) RNA m6A modification is regulated by RNA m6A regulators, including “writers”-methyltransferase, “erasers”-demethylase, and “readers”-RNA m6A binding proteins. “Writers” consist of core components METTL3, METTL14, WTAP and other factors (KIAA1429, ZFP217, RBM15, RBM15B, and CBLL1). FTO and ALKBH5 are two “erasers.” “Readers” include HNRNPC, HNRNPA2B1, YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, IGF2BP1, IGF2BP2, IGF2BP3, and EIF3A. (B) Expression profiles of RNA m6A regulators in 13 cancer types. Up represents higher expression and down represents lower expression. The circle size represents the statistical significance after controlling FDR. (C) Representative examples of expression patterns of m6A regulators across four cancer stages. *P < 0.05, **P < 0.01, and ***P < 0.001. (D) Overview of prognostic effects of m6A regulators. High represents the patients with better prognosis when gene expression level is high, and low represents the patients with better prognosis when gene expression level is low.