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. 2021 Feb 23;11:624395. doi: 10.3389/fonc.2021.624395

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Copyright © 2021 Liu, Wang, Teng, Zhang and Song

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification and analysis of key regulatory pairs in KIRC. (A) The process of building the signature using LASSO regression algorithm. (B) Biological process enrichment analysis of differentially expressed genes between high-risk and low-risk groups. (C) KEGG pathway enrichment analysis of differentially expressed genes in high-risk and low-risk groups. (D) Functional similarity analysis of gene sets in terms of biological processes. The order of enrichment items in the upper part of triangle is consistent with that of the left side. (E) Comparison of infiltration scores of 28 immune cell types between high-risk and low-risk groups. **P < 0.01, ***P < 0.001, and ****P < 0.0001.