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PTPN22 regulates macrophage polarization. (A) PTPN22620R and PEP619R inhibit cytokine secretion from M1 macrophages. Upon M1 polarization of PTPN22620W or PEP619W macrophages, there is more PTPN22620W and PEP619W present and the enhanced expression leads to an increased capacity to inhibit cytokine secretion from M1 macrophages. (B) PTPN22620R and PTPN22620W promote cytokine secretion from M2 macrophages equivalently.
