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PTPN22 genotype influence on TCR-related phenotypes.
| Phenotype | Donor genotype | ||
|---|---|---|---|
| PTPN221858C/C | PTPN221858C/T | PTPN221858T/T | |
| IFNγ production (fold change) (79) | 4.34 | * | 1.35* |
| CD4+ memory T cells that are CD25+ (%) (76) | 58 | 45 | n/a |
| IL-10 secretion from CD4+ memory T cells (pg/ml) (76) | 2,200 | 800 | n/a |
| CD4+ T cell proliferation (CFSE MFI) (79) | 1,834 | 1.8 | n/a |
| Influenza virus-specific CD4+ T cells (%) (80) | 0.23 | n/a | 0.15 |
*The PTPN221858C/T donors were included in the PTPN221858T/T donor group.
