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. 2021 Mar 10;4:321. doi: 10.1038/s42003-021-01819-6

Fig. 4. Reduced cross-talk among structural communities of chimeric PKA-CDNAJB1 relative to PKA-CWT.

Fig. 4

a Structure of PKA-C highlighting all communities and their roles in various functions and regulatory mechanisms. CHESCA community matrices for b PKA-CWT and c PKA-CDNAJB1 upon binding PKI5–24. d–e CHESCA community matrices plotted on their corresponding structures. The size of each node is independent of the number of residues it encompasses, meanwhile the weight of each line indicates the strength of coupling between the individual communities.