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. 2021 Mar 10;11:5585. doi: 10.1038/s41598-021-85044-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Drug-target network of potential targets and gene expression. (A) drug-target network. PPI = protein–protein associations obtained using STRING database.The network was created using Cytoscape version 3.7.2¹⁵. (B) Fold changes of genes showing consistent differential expression of mice in high radiation doses (i.e., 10 Gy and 12 Gy) from GSE10640, GSE6874, and GSE104121. Experiment 1 and 2 were from BLK mice 24 h post-irradiation with 10 Gy, Experiment 3–6 were from BalbC (3,5,6) and BLK (4) 6hrs post-irradiation with 10 Gy, and Experiment 7 was performed on BalbC mice 6hrs post-irradiation with 12 Gy.