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. 2021 Mar 10;11:5549. doi: 10.1038/s41598-021-85002-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of GPR139 agonist (JNJ63533054) on alarm substance-induced fear response. (A) Representative side-view video tracking of swimming behaviour at 30 min after administration of GPR139 agonist (b, 0.1 µg/g; c, 1 µg/g; d, 10 µg/g body weight, BW) and subsequent alarm substance (AS) administration. However, there were no significant differences in AS-induced fear responses including the total time spent (P = 0.4789, B), total freezing time (P = 0.6826, C), total distance swam (P = 0.7077, D), and swimming velocity (P = 0.6975, E) at the bottom of a tank among GPR139 agonist treated and control groups.