Table 5.
The total number of therapeutic drug monitoring (TDM) measurements, mean relative error (MRE) (%), mean absolute error (MAE), and percentages of predictions within 20% of the observed dose-adjusted concentrations (C/D ratio) in the validation cohort depending for different ranges of the C/D ratio in the context of modeling it and log10(C/D ratio) when treated as labels, respectively.
| Items | Modeling labels | C/D ratio range | ||
|---|---|---|---|---|
| Total range | Low range (< 22.1 μg mL−1 g−1 day) | Intermediate-to-high range (≥ 22.1 μg mL−1 g−1 day) | ||
| Total number of TDM measurements | 229 | 57 | 172 | |
| MRE (%) | C/D ratio | + 15 | + 53 | + 3 |
| log10(C/D ratio) | + 8 | + 43 | − 4 | |
| MAE (μg mL−1 g−1 day) | C/D ratio | 8.7 | 8.8 | 8.7 |
| log10(C/D ratio) | 8.9 | 7.2 | 9.4 | |
| Percentage within 20% (%) | C/D ratio | 53.71 | 33.33 | 60.47 |
| log10(C/D ratio) | 51.53 | 39.66 | 55.56 | |