Fig. 1.

Structure of Myc protein and its fundamental contributions to diverse biological processes. Myc is comprised of three domains: NTD, central region, and CTD. Highly conserved elements, Myc boxes, are staggered across these domains and involved in the functions of Myc. MBI and MBII carry out the transactivation of Myc target genes, while MB III regulates the stability of Myc. The BR/HLH/LZ motif at CTD is related to the heterodimerization with Max and DNA–protein interaction. The physiological transcription factor Myc thrives diverse fundamental biological processes, including proliferation, differentiation, transcription, translation, apoptosis, angiogenesis, DNA repair, and stromal remodeling