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. 2021 Mar 10;4:323. doi: 10.1038/s42003-021-01858-z

Fig. 2. Effects of adipocyte-specific HSL deletion on systemic energy homeostasis and adipose tissue phenotype in HFD-fed mice.

Fig. 2

a Longitudinal body weight and b fat mass in control and AHKO mice fed HFD (M, 4–24 weeks, ad libitum fed, n = 9–25 animals/genotype). c Lean mass (M, 24 weeks, HFD, ad libitum fed, n = 24 animals/genotype). d Tissue weights of non-adipose tissues (Liver, CM cardiac muscle, SM skeletal muscle [quadriceps], Panc pancreas, spleen) (M, 26 weeks, HFD, ad libitum fed, n = 7–11 animals/genotype). e Weekly food intake in HFD-fed control and AHKO mice (M, ad libitum fed, n = 4 animals/genotype). f Adipose tissue (BAT brown, PGAT perigonadal, SCAT subcutaneous) weight of 10- and 26-week-old mice (M, HFD, ad libitum fed, n = 6–11 animals/genotype). g PGAT (left) and SCAT (right) mRNA expression of immune cell markers and h genes involved in lipid metabolism relative to Cyclophilin reference gene by qPCR with the young (10 weeks) control animals arbitrarily set to 1 for each gene (M, 10 and 26 weeks, HFD, ad libitum fed, n = 4–6 animals/genotype). Data represent mean ± SEM. Statistical significance was determined by Student’s two-tailed t test. P values compare effect of genotype; P < 0.05: * for effect of genotype; # for effect of age.