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. 2021 Mar 10;12:1565. doi: 10.1038/s41467-021-21865-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a UMAP plot of all scRNA-seq data, showing a total of 34 distinct cell types that were identified. b UMAP plots showing expression levels for canonical markers of epithelial, mesenchymal, endothelial, immune, and mesothelial populations. The intensity of expression is indicated by purple coloring. c UMAP plots of normally (21% O₂-exposed; left) and aberrantly (85% O₂-exposed; right) developing lungs. Each cell is colored by mouse age as indicated by the legend. d Cluster distribution in lungs of normally and aberrantly developing mice at P3, P7, and P14. n = 6 animals/group. e Circos plot showing inferred cell communications. Cell types in the top right correspond to those with the largest changes in response to hyperoxia. These cell types are connected to the cell types expressing ligands predicted to promote this response. Ligands expressed by the same cell population are colored the same. Expression levels in UMAP plots are presented as log(TP10k + 1) values. Log(TP10k + 1) corresponds to log-transformed UMIs per 10k. Cell populations in a and d are colored as indicated by the legend in d.