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. 2021 Mar 10;12:1565. doi: 10.1038/s41467-021-21865-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a UMAP plots of principal identifiers of mesothelial cells in developing lung. Intensity of expression is indicated by purple coloring. b Percentual proportion of mesothelial cells in normally (21% O₂-exposed, gray) and aberrantly (85% O₂-exposed, purple) developing lungs at P3, P7 and P14. n = 6 animals/group. Significance was evaluated by multiple unpaired multiple Student’s t-test with Holm–Sidak correction. Data are presented as means ± SD. P value = 0.0426. c UMAP plots depicting cell identity in regard to developmental time points in (21% O₂-exposed, purple) normally and aberrantly (85% O₂-exposed, green) developing lung mesothelium. Each cell is colored by mouse age as indicated by the legend. d Exposure to 85% O₂ altered gene expression in developing lung mesothelium. 21% O₂-exposed: green, 85% O₂-exposed: red. Expression values in violin plots represent Z-score-transformed log(TP10k + 1) values. Expression levels in UMAP plots are presented as log(TP10k + 1) values. Log(TP10k + 1) corresponds to log-transformed UMIs per 10k.