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. 2021 Mar 10;11:5595. doi: 10.1038/s41598-021-84938-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Graphical representation of Odds Ratio (OR) point estimates and 95% confidence intervals (CI) for the three main CD risk alleles (p.R702W, p.G908R, p.L1007fs) under additive, genotypic, and recessive genetic models (corresponding to values in Table 3). The dotted line in the Composite panel depicts the calculated CI with corresponding calculated OR for 2 alleles under an additive genetic model; of note the point estimate (2xOR) is outside of the 95% CI for the Composite genotypic homozygous and recessive models. Diamonds correspond to estimated OR values for these same variants in the IBD Exomes Browser⁴⁹; no confidence intervals are provided.