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. 2021 Mar 10;11:5562. doi: 10.1038/s41598-021-85152-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Disease activity and galectin 9 (Gal-9) levels in tacrolimus (TAC) treatment response groups (n = 52) and controls (n = 58). PR indicates poor response to TAC (n = 22), and GR indicates good response (n = 30). (A) Disease activity score 28 (DAS28). (B) Percentage of CD3⁺ T cells expressing Gal-9. (C) Percentage of CD4⁺ T cells expressing Gal-9. (D) Gal-9 expression in plasma. Significant differences between different groups at the same time point are marked as *(P < 0.05) or **(P < 0.01). Significant differences between baseline and 12 weeks within the same group are marked as # (P < 0.05) or ## (P < 0.01).