Table 2.
Allele and genotype frequencies of rs3093023 and rs3093024 in the replication cohort.
| Genetic model | Genotypes | Cases N (%) | Controls N (%) | OR (95% CI) | P-value |
|---|---|---|---|---|---|
| Rs3093023 | |||||
| Alleles | G | 11,36 (55.15) | 1,455 (59.24) | Refer | |
| A | 924 (44.85) | 1,001 (40.76) | 1.18 (1.05, 1.33) | 5.56 × 10−3 | |
| Co-dominant model | G/G | 318 (30.87) | 443 (36.07) | Refer | |
| A/G | 500 (48.55) | 569 (46.34) | 1.12 (0.89, 1.40) | 3.34 × 10−1 | |
| A/A | 212 (20.58) | 216 (17.59) | 1.37 (1.08, 1.74) | 1.00 × 10−2 | |
| Dominant model | G/G | 318 (30.87) | 443 (36.07) | Refer | |
| A/A+A/G | 712 (69.13) | 785 (63.73) | 1.26 (1.06, 1.51) | 9.22 × 10−3 | |
| Recessive model | G/G+A/G | 818 (79.42) | 1,012 (82.41) | Refer | |
| A/A | 212 (20.58) | 216 (17.59) | 1.21 (0.98, 1.50) | 7.08 × 10−2 | |
| Rs3093024 | |||||
| Alleles | G | 1,131 (54.90) | 1,456 (59.28) | Refer | |
| A | 929 (45.10) | 1,000 (40.72) | 1.20 (1.06, 1.35) | 3.04 × 10−3 | |
| Co-dominant model | G/G | 318 (30.87) | 442 (35.99) | Refer | |
| A/G | 495 (48.06) | 572 (46.58) | 1.20 (0.99, 1.45) | 5.39 × 10−2 | |
| A/A | 217 (21.07) | 214 (17.43) | 1.41 (1.11, 1.79) | 4.63 × 10−3 | |
| Dominant model | G/G | 318 (30.87) | 442 (35.99) | Refer | |
| A/A+A/G | 712 (69.13) | 786 (64.01) | 1.26 (1.06, 1.51) | 1.04 × 10−2 | |
| Recessive model | G/G+A/G | 813 (78.93) | 1,014 (82.57) | Refer | |
| A/A | 217 (21.07) | 214 (17.43) | 1.27 (1.03, 1.56) | 2.85 × 10−2 |