Table 3.
Association of rs3093023 genotypes with IgAN phenotypes.
| A/A (n = 194) | A/G (n = 524) | G/G (n = 373) | P-value | |
|---|---|---|---|---|
| Clinical phenotypes | ||||
| Age (years) | 33.81 ± 11.66 | 33.89 ± 12.12 | 34.39 ± 12.23 | 0.673 |
| Sex (%) | ||||
| Male | 93 (47.94) | 258 (49.24) | 178 (47.72) | 0.892 |
| Female | 101 (52.06) | 266 (50.76) | 195 (52.28) | |
| SBP (mmHg) | 125.53 ± 17.14 | 124.52 ± 17.11 | 123.75 ± 16.34 | 0.298 |
| DBP (mmHg) | 80.73 ± 13.04 | 78.85 ± 11.55 | 78.68 ± 11.64 | 0.023 |
| Scr (μmol/L) | 116.03 ± 83.67 | 109.50 ± 76.23 | 101.20 ± 52.02 | 0.006 |
| eGFR (mL/min/1.73 m2) | 80.62 ± 31.50 | 84.31 ± 32.28 | 85.61 ± 29.87 | 0.062 |
| Proteinuria (g/24 h) | 2.31 ± 2.55 | 2.23 ± 2.34 | 2.15 ± 2.24 | 0.611 |
| Pathological phenotypes | ||||
| M0/M1 (%) | 25/164 (13.23/86.77) | 56/453 (11/89) | 58/297 (16.34/83.66) | 0.074 |
| E0/E1 (%) | 123/66 (65.08/34.92) | 357/152 (70.14/29.86) | 256/99 (72.11/27.89) | 0.231 |
| S0/S1 (%) | 96/93 (50.79/49.21) | 285/224 (55.99/44.01) | 208/147 (58.59/41.41) | 0.218 |
| T0/T1/T2 (%) | 100/60/29 (52.91/31.75/15.34) | 274/160/75 (53.83/31.43/14.73) | 220/105/30 (61.97/29.58/8.45) | 0.027 |
| T0/T(1+2) (%) | 100/89 (52.91/47.09) | 274/135 (53.83/46.17) | 220/135 (61.97/38.03) | 0.034 |
IgAN, IgA nephropathy; SBP, systolic blood pressure; DBP, diastolic blood pressure; Scr, serum creatinine; eGFR, estimated glomerular filtration rate; M, Mesangial hypercellularity; E, Endocapillary proliferation; S, Segmental sclerosis; T, interstitial fibrosis/tubular atrophy.