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. 2021 Feb 25;11:621154. doi: 10.3389/fonc.2021.621154

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Copyright © 2021 Peng, Chen, Li, Yang, Qin, Ma, Duan, Wang, Mao and Guo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LRIG3 inhibited glioma angiogenesis by regulating VEGFA expression. (A) qRT-PCR analysis targeting angiogenic factors in glioma cells transduced with LRIG3 and control siRNAs. (B) Western blot analysis of VEGFA, LRIG3, and GAPDH. (C) Integrated density of the bands was normalized to GAPDH in LRIG3 knockdown or overexpression glioma cells. (D) Levels of VEGFA protein in the CM from glioma cells with LRIG3 knockdown or overexpression were detected by ELISA. Data are means ± SD of 3 independent replicates. *p < 0.05; **p < 0.01; ***p < 0.001. CM, conditioned medium.