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. 2021 Feb 25;12:599296. doi: 10.3389/fimmu.2021.599296

Figure 5.

Figure 5

Bystander protection induced by NE allergy vaccines requires IFN-γ (A) Mice were sensitized with OVA and peanut-alum and treated i.n. with 3 administrations of PBS (sensitized control) or peanut-NE (PN-NE). Mice were challenged orally with OVA and IFN- γ was depleted during the challenge phase. (B) Temperature change, (C) symptoms of anaphylaxis and (D) diarrhea were monitored. (E) Hemoconcentration was determined by hematocrit. (F) Levels of MCPT-1 in the serum 60 min after challenge were determined by ELISA. Statistically significant differences (p < 0.05) are indicated by *.