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. 2021 Feb 25;12:633171. doi: 10.3389/fphys.2021.633171

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Copyright © 2021 Vishnolia, Rakovic, Hoene, Tarhbalouti, Aherrahrou and Erdmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Graph presents cGMP levels (p mol per larvae) measured from AB-wild-type larvae at 4 dpf treated with H₂O, 1, 5, and 10 μM BAY41-2272 concentration. (B) cGMP levels measured and compared from gucy1a1^+/– treated with H₂O, 1, 5, and 10 μM BAY41-2272 concentration. (C) cGMP levels measured and compared between AB-wild types, morpholino injected controls, gucy1a1-MO, gucy1b1-MO, and gucy1a1+gucy1b1-MO. Data are presented as mean ± standard deviation from n = 30 larvae per group, significance was set at p < 0.05, and stars denote the significant differences.