Table 1.
Th1/Th2 and Th17/Treg related change in NOX2-deficient mice or CGD patients.
| Cell type | NOX2 mutation | Th1 change | Th2 change | Th17 change | Treg change | Other |
|---|---|---|---|---|---|---|
| CD4+ T cell of C57BL/6 (62) | gp91phox- | IL-2 ↑ | IL-4 ↓ IL-5 ↓ | NA | NA | TNF ↑ |
| Total splenocytes of C57BL/6 (63) | gp91phox- | IFN-γ ↑ | NA | IL-17↑ | NA | NA |
| Naïve CD4+ T cells of C57BL/6 (63) | gp91phox- | IFN-γ ↑T-bet ↑ | IL-4 ↓ IL-4Rα↓ IL-5 ↓ GATA-3↓ | IL-17↑ | NA | STAT5Phosphorylation↓NA |
| PBMC from CGD patients (64) | p47phox- | NA | NA | NA | No change of CD4+CD25+ Foxp3+ cells | NA |
| Total spleen cell from C57BL/6 (65) | p47phox- | NA | NA | NA | No change of CD4+ Foxp3+ cells | NA |
| Spleen CD4 T cells of OT-II mouse (66) | p47phox- | IL-2 ↓IFN-γ↓CD4+T-bet+ cell↓ | IL-17A↓ | IL-10↓ | TNF-α↓TGF-β↓IL-5↓Il-12p70↓ |
Frequencies of Th1, Th2, Th17, Treg cells, or levels of related cytokines are compared between immune cells from NOX2 mutation mice/CGD patients and wild type mice/healthy people. ↑: levels of cytokines or frequencies of cells are higher than wild type mice/healthy people. ↓: levels of cytokines or frequencies of cells are lower than wild type mice/healthy people.