Table 3.
Th1/Th2 and Th17/Treg related change in NOX2-deficient (NCF1 mutation) NOD mice.
| Cell type and mice | Type 1 diabetes | Macrophage related change | CD4/CD8+ T cell related change | Other |
|---|---|---|---|---|
| CD4+ T cells of NOD mice (67) | Remission | NA | IFN-γ ↓, IL-2 ↓, T-bet ↓ IL-4 ↓, IL-17↑, IL-10↑ CD4+/IL-17A+ cell↑ No change of CD4+CD25+ Foxp3+ cells | TNF-α↓ TGF-β↑ |
| Spleen CD8+ T cells (70) of NOD mice | Remission | NA | CD8+/IFN-γ+ cells↓ CD8+/GzmB+ cells↓ | NA |
| BM-Mφs and CD4+ T cell of NOD mice (72) | Remission | MHC-II↑, TNF-α↓, IFN-β↓, TLR3↓, NF-κB↓ | No change of CD4+ Foxp3+ cells | NA |
| Islets and BM-Mφs with M1/M2 Polarization of NOD mice; (71) | Remission | M1 Marker↓ (cxcl10, ccl5, iNOS, TNF-α, IFN-γ,STAT1 )M2 Marker↑ (ccl17, Arg1, Retnla, CD206, STAT6) | NA | NA |
| Splenocytes of NOD.BDC-2.5 mice (73) | Exacerbation | NA | IFN-γ↑, IL-17↑ IL-2↑, IL-12Rβ2↑ Activation Markers↑ (CD25, CD44, CD69) | TNF-α↑IL-1β↑ |
Frequencies of Th1, Th2, Th17, Treg cells, or levels of related cytokines are compared between immune cells from NOX2 mutation NOD mice and NOD mice. ↑: levels of cytokines or frequencies of cells are higher than NOD mice. ↓: levels of cytokines or frequencies of cells are lower than NOD mice. BM-Mϕs, Bone marrow macrophages.