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. Author manuscript; available in PMC: 2022 Mar 19.
Published in final edited form as: J Mol Biol. 2020 Sep 11;433(6):166648. doi: 10.1016/j.jmb.2020.09.007

Figure 3. scFv-assisted cryo-EM structure determination of nucleosomes.

Figure 3.

(A) Illustration of the density maps of the scFv-nucleosome complex at 2.6 Å resolution [27]. (B) Comparison of the cryo-EM structures of CENP-A nucleosomes with 147 bp Widom 601 DNA and 145 bp α-satellite DNA. The base pair at each end of the nucleosome in the 147 bp are shown in spheres. (C) Comparison of the cryo-EM structure of the nucleosome containing 147 bp Widom 601 DNA and the crystal structure of 145 bp Widom 601 nucleosome. The extra base pairs at the ends of the 147 bp DNA are shown in spheres.