. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Ophthalmol Retina. 2020 Sep 11;5(6):580–592. doi: 10.1016/j.oret.2020.09.004

Table 6:

Comparison of macular edema and retinopathy of prematurity findings in preterm infant macular optical coherence tomography studies

	Number of infants	Gestational age Mean (SD) (weeks)	Birth weight Mean (SD) (gm)	Age at Imaging (weeks PMA)	Macular Edema (%)	ROP Stage	Association between Macular edema & ROP
Current Study	85 infants (169 eyes)	28 (2)	976 (269)	36 (0.6)	60%	0: 95 eyes 1: 29 eyes 2: 42 eyes 3: 3 eyes^*	Prevalence of macular edema increased with higher stages of ROP
Zepeda et al, 2018³⁰	65 infants	28 (2.7)	997 (286)	34 (3)	40%	0: 43 eyes 1: 8 eyes 2: 4 eyes 3: 10 eyes	Association between macular edema and ROP not tested in this study.
Erol et al, 2014¹¹	179 infants (358 eyes)	30.9 (2.7)	1609 (477)	38.2 (3.9)	38%	1: 82 eyes 2: 28 eyes 3: 16 eyes	The presence of macular edema increased with increasing ROP stage
Dubis et al, 2013¹²	46 infants	27 (3)	914 (358)	30-57	56%	0: 17 infants 1: 4 infants 2: 8 infants 3: 12 infants 4A: 2 infants	No association between the most severe ROP stages and the presence of macular edema
Maldonado et al, 2012⁸	42 infants	26 (1.8) (median)	760 (272) (median)	34 (1.6) (median)	50%	0: 13 infants 1: 6 infants 2: 17 infants 3: 6 infants	Increased severity of edema was associated with plus disease, higher ROP stage and subsequent laser treatment
Vinekar et al, 2011¹⁰	74 infants (146 eyes)	31.2 (2.32)	1282	37 (2.7)	29% of stage 2	1: 27 eyes 2: 79 eyes	Macular edema was present only in Stage 2 eyes

SD: Standard deviation; PMA: postmenstrual age; ROP: retinopathy of prematurity

Stage 3 not included in the analysis due to small numbers