. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Eur J Nutr. 2020 Sep 11;60(4):1921–1934. doi: 10.1007/s00394-020-02377-z

Table 2:

Linear models for change in ln(homocysteine) over 12 weeks, by baseline plasma folate strata.^a

Change (week 12 - week 0)	Low strata (≤ median)		High strata (> median)		Test for difference between strata ^b
Treatment vs. placebo	B (95% CI)	P	B (95% CI)	P	P	FDR

400FA	−0.33 (−0.43, −0.23)	<0.001	−0.16 (−0.25, −0.08)	<0.001	0.011	0.024
800FA	−0.34 (−0.45, −0.23)	<0.001	−0.20 (−0.29, −0.11)	<0.001	0.049	0.065
Creatine	−0.05 (−0.15, 0.06)	0.38	−0.02 (−0.11, 0.07)	0.67	0.70	0.70
Creatine+400FA	−0.31 (−0.42, −0.21)	<0.001	−0.14 (−0.22, −0.05)	0.002	0.012	0.024

FDR = false discovery rate.

^a.

Placebo used as reference group. Baseline plasma folate median = 13.50 nmol/L.

^b.

Wald test for difference between low and high strata.