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. 2021 Feb 25;11:586771. doi: 10.3389/fonc.2021.586771

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Copyright © 2021 Huang, Tian, Zhang, Liu and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rab12 induced more G2/M arrest by regulating cell cycle-related proteins after radiation. (A, C) Flow cytometry analysis of the effect of Rab12 knockdown and overexpression on cell cycle distribution 24 h after radiation at 6 Gy (stained with PI), G1, G2 phases are indicated; (B, D) Cell cycle related proteins before and after radiation in Rab12 knockdown and overexpression cells were detected by Western blot. Comparable Western blots were observed in three independent experiments. Data are presented as mean ± SD from three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001.