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. 2021 Feb 25;12:602277. doi: 10.3389/fimmu.2021.602277

Figure 2.

Figure 2

Factor H domains involved in binding to the host and pathogens. FH contains 20 complement control protein modules (CCP) each with about 60 amino acids linked by three to five amino acids. In the top panel, FH domains necessary for its regulatory function and domains interacting with C3 fragments and polyanions are indicated. In the bottom panel, overlapping FH domains involved in binding pathogens are indicated. Refer to Table 1 for specific FH domains involved in binding to individual pathogens and for pathogens binding FH through undefined domains.